selective cyclization and is omerization of 3-propargylthio- 1,2,4- benzotriazine to thiazolo [2,3-c] [1,2,4] benzotriazine
نویسندگان
چکیده
the method cited in the literature for synthesis of 1,2- dihydro 3- thioxo - 1,2,4- benzotriazine 1 was improved .1 was condensed with propargyl bromide to afford 3 - propargylthio – 1,2,4 -benzotriazine 5. transformation of this compound to 9h-3- methylthiazolo [2,3-c] [1,2,4] benzotriazine ( 3, r = me) was performed in the presence of na o me / meoh . orientation of this selective cyclization was ascertained by (n.o.e.) nmr experiment
منابع مشابه
SELECTIVE CYCLIZATION AND IS OMERIZATION OF 3-PROPARGYLTHIO- 1,2,4- BENZOTRIAZINE TO THIAZOLO [2,3-C] [1,2,4] BENZOTRIAZINE
The method cited in the literature for synthesis of 1,2- dihydro 3- thioxo - 1,2,4- benzotriazine 1 was improved .1 was condensed with propargyl bromide to afford 3 - propargylthio – 1,2,4 -benzotriazine 5. Transformation of this compound to 9H-3- methylthiazolo [2,3-c] [1,2,4] benzotriazine ( 3, R = Me) was performed in the presence of Na O Me / MeOH . Orientation of this selective cy...
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Selective transformation of 2-propargylthio-6-methyl-pyrimidin-4(1H)On e (2) to 3,5-dimethyl-7H-thiazolo [3,2-a] pyrimidin-7-one (3) is performed under the conditionof base catalysis . For elucidation of structure, palladium catalyzed cyclization reaction of (2) was carried out and the structures of the products were assigned (5) and (6). These compounds underwent isomerization to (3) and (4...
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J. McGraw, Editors. 2006. Harvard University Press, Cambridge, Massachusett s. Vol. 1, Mechanisms and Measurements: ix + 589 pp., 32 color plates; ISBN 0-674-01893-1. Vol. 2, Function and Evolution: x + 477 pp., 32 color plates; ISBN 0-674-02176-2. Hardbound, $95.00 each.—In his now classic Animal Biochromes and Structural Colours (1953), Denis Fox surveyed the “physical, chemical, distribution...
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selective transformation of 2-propargylthio-6-methyl-pyrimidin-4(1h)on e (2) to 3,5-dimethyl-7h-thiazolo [3,2-a] pyrimidin-7-one (3) is performed under the conditionof base catalysis . for elucidation of structure, palladium catalyzed cyclization reaction of (2) was carried out and the structures of the products were assigned (5) and (6). these compounds underwent isomerization to (3) and (4) r...
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Tirapazamine (1) is a promising antitumor agent that selectively causes DNA damage in hypoxic tumor cells, following one-electron bioreductive activation. Surprisingly, after more than 10 years of study, the products arising from bioreductive metabolism of tirapazamine have not been completely characterized. The two previously characterized metabolites are 3-amino-1,2,4-benzotriazine 1-oxide (3...
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عنوان ژورنال:
journal of sciences islamic republic of iranجلد ۱۰، شماره ۱، صفحات ۰-۰
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